Subject(s)
Acidosis/chemically induced , Adult , Animals , Dogs , Humans , Male , Myoglobinuria/chemically induced , Poisoning/blood , Seizures/chemically induced , Strychnine/metabolismABSTRACT
A case of middle aged male who developed swelling and weakness of muscles in the lower limbs following a heavy binge of alcohol is being reported. He had myoglobinuria and developed acute renal failure for which he was dialyzed. Acute alcoholic myopathy is not a well recognized condition and should be considered in any intoxicated patient who presents with muscle tenderness and weakness.
Subject(s)
Alcoholic Neuropathy/complications , Humans , Acute Kidney Injury/chemically induced , Male , Middle Aged , Muscular Diseases/complications , Myoglobinuria/chemically induced , Rhabdomyolysis/chemically inducedABSTRACT
Eight hours following tympanoplasty performed under general anaesthesia (sodium pentothal and trichloroethylene), a 30 year old male complained of muscular weakness and dark coloured urine. Urinalysis revealed myoglobin pigment. A rise in BUN (47mg%), serum creatinine (5.7mg%), creatinine phosphokinase (15,500 U/L) and CPK-MB fraction (4690 U/L) was noticed 36 hrs later. The patient developed acute renal failure, and recovered after haemodialysis. From a history of use of succinylcholine as a muscle relaxant during operation, myoglobinuria appears to be secondary to muscle damage caused by succinylcholine.